EdenteV2, Main, Exploration, bibRecord, 006039

Diffusion-weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia.

Identifieur interne : 006039 ( Main/Exploration ); précédent : 006038; suivant : 006040

Diffusion-weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia.

Auteurs : Abdesslem Khiat [Canada] ; Yevgeniy Kuznetsov ; Pierre J. Blanchet ; Yvan Boulanger

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18512744

Descripteurs français

KwdFr :
- Acathisie due aux médicaments (diagnostic), Adulte d'âge moyen, Bouche édentée (physiopathologie), Femelle, Humains, Imagerie par résonance magnétique de diffusion (), Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement d'image par ordinateur (), Troubles de la motricité (diagnostic).
MESH :
- diagnostic : Acathisie due aux médicaments, Troubles de la motricité.
- physiopathologie : Bouche édentée.
- Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique de diffusion, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement d'image par ordinateur.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Akathisia, Drug-Induced (diagnosis), Diffusion Magnetic Resonance Imaging (methods), Female, Humans, Image Processing, Computer-Assisted (methods), Male, Middle Aged, Mouth, Edentulous (physiopathology), Movement Disorders (diagnosis).
MESH :
- diagnosis : Akathisia, Drug-Induced, Movement Disorders.
- methods : Diffusion Magnetic Resonance Imaging, Image Processing, Computer-Assisted.
- physiopathology : Mouth, Edentulous.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.

Abstract

Oral dyskinesias occur in elderly individuals in relation to drug use (tardive dyskinesia, TD) or edentulousness (edentulous orodyskinesia, EOD) but their characterization remains incomplete. Our aim was to investigate whether magnetic resonance techniques such as diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug-treated patients with TD, 12 EOD patients, 8 drug-treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons.

DOI: 10.1002/mds.22081
PubMed: 18512744

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Oral dyskinesias occur in elderly individuals in relation to drug use (tardive dyskinesia, TD) or edentulousness (edentulous orodyskinesia, EOD) but their characterization remains incomplete. Our aim was to investigate whether magnetic resonance techniques such as diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug-treated patients with TD, 12 EOD patients, 8 drug-treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons.</div>
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Diffusion-weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia.

Diffusion-weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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